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Research Think Tank Risk Factors

Research think tank about the risk factors.

The Research Think Tank (RTT) Risk Factors Work Group focused on unanswered questions about what increases the risk of young women developing breast cancer. These risk factors likely differ from what causes the disease in older women.

The group was composed of advocates:

  • Deb Aruta (chair)
  • Diana Chingos
  • Nancy Sauers
  • Medha Sutliff

As well as physicians/researchers:

  • Dr. W. Archie Bleyer
  • Dr. Brian Czerniecki
  • Ms. Jennifer Ivanovich
  • Dr. Rebecca Johnson
  • Dr. Jose Russo
  • Dr. Irma Russo

Research Priorities

Three of the 19 research priorities recommended by the RTT focused on risk factors. Below we list the priority, indicate any progress made since the RTT and list any open trials of which we are aware related to or focusing on these research priorities.

Are there modifiable risk factors that can prevent early onset breast cancer?

Progress Made: Work In Progress


Recent research updates:

Triple negative breast cancer appears to be inversely associated with a young woman’s decision to breastfeed. Read More

Long-term oral contraceptive use is associated with a higher risk of breast cancer in young women, especially for triple negative breast cancer, but validation and additional studies are needed. Read More

Relationship of obesity and ethnicity on risk of premenopausal breast cancer was examined, with an inverse relationship for African Americans and Caucasians and a positive association in Asian women. Read More

Early age at first pregnancy, obesity and consumption of alcohol associated with reduced risk of early onset breast cancer. Read More

Current research initiatives/studies:

Phase II Study of Metformin for Reduction of Obesity-Associated Breast Cancer Risk (overweight premenopausal women)


Are there specific environmental exposures (in utero, childhood, adolescence and beyond) that increase the risk of early onset breast cancer?

Progress Made: Thumbs Down


What are the unidentified genetic risk factors that contribute to the risk of early onset breast cancer?

Progress Made: Work In Progress


Recent research updates:

A variety of genetic mutations were found in this sampling of women with early onset breast cancer, but few mutations are currently actionable. Read More

HER2+ early onset breast cancer may be influenced by inherited TP53 mutations. Read More

Current research initiatives/studies:

The ABOUT network is a patient-powered research registry created and governed by and for people affected by hereditary breast and ovarian cancer.

Get in Touch

If you believe we are missing a crucial piece of research or have not included a research study which should be here, please contact us!

Related Topics

Research Think Tank Fertility Work Group

The Research Think Tank (RTT) Fertility Work Group focused on unanswered questions relating to a young woman maintaining her fertility throughout breast cancer treatment. It also addressed the use and safety of fertility preservation.
Research Think Tank Metastasis Work Group

Research Think Tank Metastasis Work Group

The Research Think Tank (RTT) Metastasis Work Group focused on the unique issues and concerns of young women diagnosed with metastatic breast cancer.
Research Think Tank Pregnancy Work Group

Research Think Tank Pregnancy Work Group

The Research Think Tank (RTT) Pregnancy Work Group focused on unanswered questions relating to all aspects of breast cancer and pregnancy. These included breast cancer treatment during pregnancy, postpartum breast cancer and the safety of pregnancy after breast cancer.
Research Think Tank Quality of Life Work Group

Research Think Tank Quality of Life Work Group

The Research Think Tank (RTT) Quality of Life Work Group focused on unanswered questions about a young woman's life and side effects during and after breast cancer treatment.
Research Think Tank Treatment Work Group

Research Think Tank Treatment Work Group

The Research Think Tank (RTT) Treatment Work Group focused on unanswered questions about the most optimal treatment of breast cancer in a young woman and how that treatment may differ from that given to an older woman.

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