What are ovarian suppression and ovarian ablation?

Ovarian suppression and ablation refer to the cessation (stopping) of the production of natural hormones by the ovaries to block those hormones (estrogen and progesterone) from reaching cancer cells and causing them to grow.

  • Ovarian suppression: A pharmaceutically induced menopause. Women will experience a gradual change, which is close to the effects of natural menopause. The long term risks and benefits of ovarian suppression drugs, taken in combination with drugs like tamoxifen and chemotherapy, are currently being researched. There are currently three trials (SOFT, PERCHE, and TEXT), which you can get information about by visiting the Clinical Trials sections of our website.
  • Ovarian ablation: Achieved through the surgical removal of the ovaries (oophorectomy). Young women who experience ovarian ablation experience menopause immediately and permanently, and the side effects are likely to be more severe than the effects of natural menopause.
Hormonal Treatments