Clinical Trials Listing

Young Survival Coalition
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Research & Trials
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Clinical Trials Listing

ST Trials - Tailored treatment investigations for premenopausal patients with endocrine-responsive disease

E2Z04: Quality of Life in Younger Breast Cancer Survivors

ST Trials - Tailored treatment investigations for premenopausal patients with endocrine-responsive disease

The STP trials are three trials investigating the optimal hormone therapy for premenopausal women. STP stands for the names of the trials -- SOFT, TEXT and PERCHE. Each is briefly explained below.

Study Name:	SOFT: Suppression of Ovarian Function Trial (IBCSG 24-02)
Institution:	Various
Purpose of Study:	This randomized phase III trial is being conducted to compare the effectiveness of ovarian suppression plus either tamoxifen or exemestane with that of tamoxifen alone in treating premenopausal women who have undergone surgery for hormone-responsive breast cancer.
Eligibility:	- No more than 6 months since chemotherapy - No distant metastases - Cancer in one breast only - No previous breast cancer - More than 1 year since hormone therapy (such as tamoxifen or raloxifene) or hormone replacement therapy - No more than 6 months of hormone therapy after receiving the diagnosis of breast cancer - No previous radiation therapy to the ovaries - No previous surgery to remove both ovaries

Contact: http://cancer.gov/clinicaltrials/view_clinicaltrials.aspx?cdrid=316456&protocolnum=&version=patient&protocolsearchid=

Study Name:	TEXT: Tamoxifen and Exemestane Trial (IBCSG 25-02)
Institution:	Various
Purpose of Study:	This randomized phase III trial is being conducted to compare the effectiveness of combining triptorelin with either exemestane or tamoxifen in treating premenopausal women who have hormone-responsive breast cancer.
Eligibility:	- Previous surgery to completely remove the tumor - No distant metastases - Cancer in one breast only - No previous breast cancer - No previous chemotherapy - No previous hormone therapy since receiving the diagnosis of breast cancer - No previous radiation therapy to the ovaries - No previous surgery to remove both ovaries

Contact: http://cancer.gov/clinicaltrials/view_clinicaltrials.aspx?cdrid=316458&protocolnum=&version=patient&protocolsearchid=

E2Z04: Quality of Life in Younger Breast Cancer Survivors

Purpose of Study: This clinical trial is studying quality of life in female breast cancer survivors and their spouse, partner or acquaintance.

Objectives:

Compare the quality of life (physical functioning, psychological functioning, social functioning, and spiritual functioning) of female breast cancer survivors who were age 45 or younger at the time of diagnosis with the quality of life of female breast cancer survivors who were age 55 to 70 at time of diagnosis (considering type of surgical treatment [lumpectomy vs mastectomy], hormonal treatments, and time since diagnosis as covariates) and age-matched (to the younger group) females with no history of breast cancer.
Compare the quality of life (physical functioning, psychological functioning, social functioning, and spiritual functioning) of partners of breast cancer survivors who were age 45 or younger at time of diagnosis with the quality of life of partners of breast cancer survivors who were age 55 to 70 at diagnosis and partners of age-matched (to the younger group) females with no history of breast cancer.

Elgibility: Ages Eligible for Study: 18 Years - 78 Years, Genders Eligible for Study: Female

Criteria:

Disease Characteristics:

Patient: Female breast cancer survivor with age at initial diagnosis in 1 of the following ranges: 18-45 or 55-78
Must have enrolled and participated in ECOG study CLB-9741, E-1199, or E-2197
Must have received chemotherapy at least 3 years, but no more than 8 years prior to this study entry
Disease free at the time of this study entry

Spouse or partner of the patient, age-matched female acquaintances of the patient (in the younger patient group), or partner of acquaintances:

Spouse or partner of the patient may be either gender
Age-matched female acquaintance is defined as within 5 years of age difference of the patient in younger group (18-45 years of age)
With a similar level of education and race of the patient
Not a personal friend of the patient
No history of breast cancer

Paitent Characteristics:

Must reside in the continental U.S. and speak English (for patients)

Contact: http://clinicaltrials.gov/ct/show/NCT00309933;jsessionid=BC0784910346DF97E34FBF35CC8F8EB8?order=41